Dr. Laura: Dairy and hormone based cancers

There are mixed reviews on dairy consumption in hormone based cancers.  
Fortunate for Canadians, their milk supply is protected from added hormones, where the US supply is not. If you go for organic, is it better? Organic dairy is GMO-free which should technically then be free of hormone mimickers like organophosphate and glyphosate. Is this all we have to worry about?

Insulin growth factor


There’s more to the story of dairy and hormones. Insulin growth factor (IGF-1) is in all dairy products, naturally. Even natural organic milk will have it. IGF-1 both protects aging bones and has the potential to aggravate hormone based cancers. It seems that IGF-1 prevents cells from dying when they should and thus has the potential to promote the spread of existing breast cancer cells. From this we might conclude that less IGF-1 (less dairy) in the diet may reduce the spread of an existing hormone based cancer. Research continues.

“A 3 serving increase in milk consumption per day is associated with an 18.6% (95% CI= 0.9% to 39.3%) increase in free IGF-I levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978780/



For breast cancer survivors research says to reduce dairy. At 1/2 c a day of yogurt, this may be enough to have reduced, but this is a decision you will have to make for yourself, given the facts we know and the ones we may not yet know.

What about the bones?

After estrogen deprivation therapies, the bones are often weakened. For protection, protein (about 1g per kg of body weight per day), weight bearing exercise as well as your mineral matrix is important.

Calcium supplementation should not exceed 500mg. Daily recommended intake of calcium is about 1200-1500mg per day. Many dairy alternatives like almond or cashew milk are supplemented with calcium. Food sources include canned salmon with the bones in it, sesame seeds, broccoli, dark leafy greens, chia seeds and molasses. Although spinach is high in calcium it not easily available as it is also high in oxalates that bind it.

Decisions about health are personal. We make the best decisions we can with the information we know at the time.

Here are some other related links you might like to check out:

Canada protects its milk supply from added hormones: https://albertamilk.com/ask-dairy-farmer/ive-started-buying-organic-milk-based-on-the-assum/

For GMO free: http://organicmeadow.com/ENGLISH-FAQ.htm

“IGF-I is an essential factor for longitudinal bone growth. IGF-I can also exert anabolic effects on bone mass during adulthood.” https://academic.oup.com/ajcn/article/99/5/1256S/4577510 

Effective inhibition of IGF signal transduction should be included in combinations of targeted drugs designed to treat metastatic oestrogen receptor-positive breast cancers.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722749/

About the author:Dr. Laura M. Brown ND is a Naturopathic Doctor with a Functional Medicine approach. She is a Certified Gluten Practitioner, A HeartMath Certified Practitioner and is a graduate of Adapt Level 1 at Kresser Institute of Functional Medicine. Essentially, Dr. Brown helps people better digest their food and the word around them. More at www.naturalaura.caand  www.forwardhealth.ca

Dr. Laura: Dangers of Proton Pump Inhibitors

Proton Pump Inhibitors, or PPI’s may help gastrointestinal reflux (GERD) in the short term, but they increase risk of many long term negative effects.

Long Term Side Effects of PPIs

When proton pump inhibitors are taken for an extended length of time, they can ™cause a shift in the gut microbiome that –increases risks for:

  • liver disease like alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis
  • increased risk for cardiovascular events, kidney disease and dementia. 
  • Nutritional deficiencies, especially B12 and iron.


GERD

™Gastro-esophageal reflux disease (GERD) is caused from a faulty lower esophageal sphincter valve. ™Backs up content of stomac acid burns™ the esophageal lining. For many, a trip to the conventional doctor mean a prescription of proton pump inibitors – a drug that often ends in an -prazole. Like omeprazole, pantoprazole, for example.

Causes of GERD

  • bacterial overgrowth
  • lazy sphincter
  • food sensitivity

Interesting fact is the real cause of GERD may be from not enough stomach acid, rather than too much. If this is the case, taking a proton pump inhibitor, which lessens stomach acid can actually make the problem worse. Tests for H. pylori, a bacteria that can sometimes overgrow in the stomach may be necessary. H. pylori likes to reduce the level of stomach acid so it can thrive. Lower stomach acid means food is not properly digested and this can lead to fullness in the stomach and regurgitation or GERD.

The gastric-esophageal sphincter may be lazy and in need of tonification. Proton pump inhibitors won’t address this issue, however botanical medicine can often help.

Another reason to skip the proton pump inhibitor and look for the root cause is that GERD is often a result of food sensitivity. Food sensitivities related to GERD can be more than the typical caffeine, peppermint, spicy foods and citrus that commonly aggravate the issue.

For help with this and more digestive concerns, book online, contact drlaurambrown@forwardhealth.ca or call 519 826 7973 to book your appointment today.


Dr. Laura: Why do processed foods get such a bad wrap?

Advanced Glycated End products

AGES– Advanced Glycated End products area product of food processing. AGEs appear to stimulate chronic low-grade inflammation and promote oxidative stress and affect the pancreatic beta cell function leading to the development of insulin resistance. Stop AGE diets in animal models and diabetes stops.

Bad Fats

Fats– Not all are created equal! Processed foods use trans fats to prolong shelf life, saturated fats because they are cheap and tasty. Transfats and arachadonic acids create inflammation in the body. This increases risk for plaques in the vascular system, increases cholesterol and ultimately blood pressure. In contrast, when healthy fats like omega 3 fatty acids (aka high quality fish oil) the inflammation markers go down, the cell is better able to perform its function. Since every cell has a phospholipid bilayer. This means that every cell’s skin is made of fat. When fat is of a fluid nature, nutrients are able pass in and out more effectively and the cell’s function is optimized.

Food Dyes

Dyes–The processed food industry uses food dyes to add colour to colourless foods, to enhance colour and to avoid colour loss due to environmental elements and to preserve consistency when there are variations in the colour of food. Food dyes are know to cause inattention, hyperactivity, irritability, temper tantrums or trouble sleeping.

Sugars

Sugar & high fructose corn syrup. Most processed foods have some sugar added including soda pop, breads, cereals, yogurts, processed meats, soups and condiments. High-sugar diets may make a significant contribution to cardio-metabolic risk.  High fructose corn syrup, when digested by the body produces reactive carbonyls, which creates tissue damage. Countries using high-fructose corn syrup had rates of diabetes that were about 20% higher than countries that didn’t mix the sweetener into foods, even when total sugar and total calories remain the same.

Salt

Salt– Processed foods use salt to help preserve it and for added flavour. The amount of salt in restaurant and packaged foods are the main culprits in the Western diet, not the salt added to home-prepared whole foods.  Research shows that the average North American consumes 4000mg sodium per 2000kcal diet. This is almost twice as much as the 2300mg/day recommend by some health experts. If the amount reduces even to 2700mg/day, a 5mmHg smaller rise in systolic blood pressure would be noted in those 25-55 years of age. This results in an estimated 150,000 lives saved from death due to cardiovascular events. The kicker is, if not getting annual checkups, often the first sign of high blood pressure, is a deadly heart attack.

White Flour

White flour  – Without the fibre, white flour easily breaks down quickly into simple carbohydrates, which is essentially sugar to the body. Processed foods are full of white flour. The fast breakdown quickly elevates blood sugar, induces insulin release and quickly and causes cravings for more sugar to restore blood sugar levels. The cycle easily repeats itself as quick carbs are continually fed into the body. Over time and continued food abuse, the insulin that works diligently to get the sugar into the cells, becomes less effective, the sugar stays in the blood stream and the person is now experiencing high blood sugar levels and insulin resistance… a path well travelled to the diabetes destination.

Dr. Laura: Boost your energy

The energy powerhouses of cells are called mitochondria. These tiny organelles are derived solely from our mother’s DNA and are reposible for generating the energy our bodies need to run.

Mity Mitochondria

  • Make up about 10% of our body weight
  • 200-2000 per body cell
  • relies on the fats, carbohydrates and proteins we eat
  • loves to run on ketones
  • Needs nutrients like calcium, B vitamins, CoQ10, N-Acetyl-Cysteine, Magnesium, Alpha lipoid acid, lysine

Energy Drains

Fatigue comes from drains on the mitochondrial function. This can happen with any type of toxic burden:

  • long term nutrient deficiency
  • poor sleep habits
  • hormonal disruption
  • eating too much in general
  • eating too much sugar
  • excessive exercise
  • heavy metals
  • viruses and spirochetes (Lymes)
  • pesticides
  • plastics, PCB’s
  • drugs
  • mold

Signs of Mitochondrial Dysfunction

Unexplained fatigue, the need for more than 8 hours of sleep on an ongoing basis, poor exercise recovery, impaired sense of smell or taste, headaches, poor motivation, depression, anxiety, brain fog, forgetfulness, extra sensitive to light and noise – are all indicators of poor mitochondrial dysfunction. While other things may be at play like poor thyroid function, hypothalamus, pituitary or adrenal function, it is important to also consider the mitochondria.

Boost Your Energy

Support the mitochondria and reclaim your energy. An initial naturopathic appointment will start the process to understand the source of your energy drain. Together a same day plan could initiate the changes required to boost energy.

Dr. Laura M. Brown, ND

Dr. Laura: 5 ways to strengthen your immune system

Immune system need a boost? Support it with one or a combination of these top five natural ways. A strong immune system means less colds and flu, especially through this winter and early spring season.

As a start, be sure to wash your hands regularly with soap and water keep indoor humidity around 45-50%. Then, visit your naturopathic doctor to find what is the best combination of these five following things you need to strengthen your immune system.

1. Probiotics

2. Adaptogens

3. Medicinal Mushrooms

4. Vitamins

5. Minerals

 

Probiotics

We know that 70% of your immune system resides in the gastrointestinal tract, so it makes perfect sense to keep a healthy balance of your microflora. Research in probiotics is very active and there may be new strains available to help you balance yours.

Adaptogens

The adrenal glands are little hat like glands that sit atop the kidneys.  When you think of cold weather, think of hats and think of adrenal support. Resilience to stress can keep illness at bay but when we are constantly under stress at work, at home and toxins build up from pesticides, environmental factors, drugs, allergens – we need help. There are a number of adaptogenic herbs like holy basil, ashwagandha, ginsengs, liquorice, schisandra, codonopsis, astragalus and rhodiola that can be custom blended to support your needs.

Medicinal Mushrooms

Medicinal mushrooms can be an amazing support for the immune system. Helpful are hot water extracts of mushrooms like maitake (Grifola frondosa), reishi (Gandoderma lucidum), Cordyceps, shitake (Lentinus edodes), turkey tail (Coriolus versicolor), and sun mushroom (Agaricus blazei). It is possible to get these in different combinations and even in packets to make a “tea”.

Vitamins

Vitamin A, C, E top the list for immune support. Oranges, citrus and bell pepper provide Vitamin C.    The beta-carotene in orange and red vegetables will convert to Vitamin A in most people. Cod liver oil is a viable direct source of vitamin A.  Wheat germ oil and almonds pack a punch of vitamin E. There are formulas available that combine these vitamins with some minerals and they can often be a sure way of getting the support you need every day.

Minerals

Zinc, Selenium and Magnesium are truly critical for the immune system to function. A varied diet will often provide enough. Bone soup broths are a great, as are pumpkin seeds for the zinc, brazil nuts for the selenium and dark leafy greens for the magnesium.

 

This blog does not constitute medical advice. Natural products can interfere with existing medical conditions and prescription drugs. Be safe and get the knowledge and advice of a naturopathic doctor.

From the heart and mind of Dr. Laura M. Brown, ND

Dr. Phil Shares: Menopause Belly: Why Fat Accumulates & How to Tackle It?

 

Many women notice after age 45 that fat seems to accumulate readily at the waist. There are even terms for it, like menopause belly, muffin top, or “meno-pot.” What does the science tell us about menopausal belly fat and how to get rid of it? What are the hormonal drivers and are they amenable to change with personalized lifestyle medicine? Certainly belly fat, specifically subcutaneous and visceral abdominal fat, increases during menopause,1-3 when the changing hormonal environment can bring with it a remodeling of fat storage patterns. Abdominal fat, especially visceral fat, is biochemically different and more metabolically active than fat stored in other areas, secreting more pro-inflammatory cytokines and adipokines.4 That means preventing or reversing belly fat is not just a vanity project, it’s a meaningful step in managing a woman’s overall health, as abdominal fat has been consistently linked with insulin resistance, impaired glucose control, and overall higher cardiometabolic and breast cancer risk. Practitioners are often asked ‘How can I get rid of menopausal belly fat?’, and it is important to remember that effective management is multifaceted – encompassing an understanding how changes in sex steroids interact with other endocrine systems and also with lifestyle choices, and recognizing the best time to implement a lifestyle medicine approach is in the years before a woman’s final menstrual period.

The changing hormonal environment

A robust understanding of the hormonal changes associated with perimenopause and menopause can guide women toward effective intervention. Here are the top five hormonal changes associated with the menopausal transition.

  • Changes in estrogen and estrogen dominance: Menopause is often framed simply as the loss of estrogen, but the road from pre- to post-menopausal estrogen levels is not necessarily smooth. Although loss of estrogen itself is linked with increasing abdominal fat,2,3 paradoxically the estrogen dominance that occurs in perimenopause and that may continue into menopause is seen clinically as a culprit in expanding abdominal fat mass.5 Between age 35 and 45, most women are beginning to run low on ripe eggs and experience hormonal changes linked with advancing reproductive age.6 During this time reduced progesterone coupled with high and erratic estrogen occurs.6,7 Estrogen declines but is in relative excess to progesterone. This is the definition of estrogen dominance: having a progesterone level that’s less than 100X the level of estrogen, creating an imbalance in the estrogen-progesterone partnership and essentially an inadequate level of progesterone to keep estrogen in check. Local estrogen production in adipose tissue can also contribute to estrogen dominance during this time. For example, aromatase enzymes, responsible for converting androgens to estrogens, are more active in visceral adipose tissue of post-menopausal women in response to cortisol.8

 

  • Cortisol: Dysregulation of the HPA axis and cortisol excess can manifest as increased central and visceral fat mass and metabolic disturbances such as insulin resistance.9,10 Increased production of cortisol,11 and conversion of cortisone (inactive) to cortisol (active) has been described in post-menopausal women,12 indicating that increased cortisol synthesis and conversion could contribute to metabolic dysfunction in these women. Cortisol is regulated in part by sex steroids, and estrogen down-regulates the expression and activity 11β-HSD1, the enzyme involved in converting inactive cortisone to active cortisol13 – so higher estrogen, lower 11β-HSD1 and less active cortisol formed. Declining estrogen levels during menopause can have a knock-on effect on cortisol formation, and 11β-HSD1 has been shown to be upregulated particularly in visceral fat in post-menopausal compared with pre-menopausal women. 1,11,12 As well as contributing directly metabolic dysfunction, higher cortisol can feed back to hormonal environment and contribute to estrogen dominance occurring at this time through cortisol-induced aromatase activity.8,14

 

  • Insulin: Fat cells accumulating in the abdomen is linked with insulin resistance. The pro-inflammatory cytokines produced by abdominal fat interferes with insulin signaling.15 This results in insulin resistance where cell response to insulin is lost, which creates a cycle where greater production of insulin is required to manage blood glucose levels. Insulin is a gatekeeper of metabolism, and rising insulin levels can set off a chain reaction that ultimately leads to a cycle of weight and abdominal fat gain. Insulin can lower production of sex hormone binding globulin (SHBG) in the liver.16,17 Lower SHBG results in greater free androgens and estrogens in circulation, and is linked with visceral fat and insulin resistance in menopausal women.18,19 In addition, insulin resistance can have a knock-on effect on leptin, insulin’s cousin.

 

  • Leptin: Leptin is the put-down-your-fork hormone, the one that tells you when you are full.20 Elevated insulin levels eventually lead to elevated leptin, which despite what you may think, does not mean you are more likely to put down your fork and stop eating. Instead, consistently elevated leptin levels lead to a dysfunction of leptin receptors and they stop sending signals to the brain to tell you to stop eating – this is called leptin resistance.21 The mechanisms driving leptin-resistance are complex, but high intakes of refined carbohydrates have linked with its development.22

 

  • Thyroid hormones: Thyroid hormones, which regulate how quickly we burn calories and maintains our metabolism, can becomes unbalanced with age, a trend that has been labeled ‘thyropause’. If the thyroid becomes underactive, this can lead to symptoms including weakness, fatigue, and weight gain.23

What can be done?

One of the biggest myths in women’s health is that once hormones change with menopause, abdominal adiposity is immovable – however addressing modifiable hormones such as cortisol and insulin in the following ways can have an impact.

  • Make foundational changes to dietary intake. When evaluating diet, consider factors that influence insulin levels, such as high carbohydrate intakes or intake of refined carbohydrates which require greater insulin response to manage spikes in plasma glucose. Remove inflammatory or trigger foods, as inflammation can contribute to insulin resistance.31 Add in foods rich in antioxidants which promote detoxification. Eliminate alcohol which robs you of deep sleep and lowers metabolism by more than 70% for 24 hours. Choosing when to eat during the day can also make a positive impact to insulin levels and insulin sensitivity. Time-restricted feeding (TRF) protocols, a type of intermittent fasting, where food is consumed during a limited number of hours per day (often 6 or 8) has been shown to reduce body weight and abdominal fat32 and improve insulin sensitivity even without weight loss.33

 

  • Add more movement to the day. Sitting is like the new smoking. Approximately 35 chronic diseases and conditions are associated with sedentariness, and sedentary behavior makes people more prone to gain body fat.24 High intensity interval training (HIIT) is effective at reducing abdominal and visceral adiposity, as well as improving insulin sensitivity and building muscle.25,26 Studies in post-menopausal women show that HIIT training results in greater abdominal and visceral fat mass loss compared to continuous exercise programs (where heart rate was maintained at a constant level)27,28 showing that HIIT is a time-efficient strategy for improving central obesity in this population. In addition to HIIT programs, practicing yoga can be recommended for menopausal women, showing significant reductions in menopausal symptoms.29 In broader populations, interventions that included yoga asanas were associated with reduced evening and waking cortisol levels, as well as improved metabolic symptoms.30

 

  • Support reparative sleep. A primary step to losing belly fat is to get enough sleep and to make it quality sleep. Epidemiological studies have repeatedly shown links between sleep duration and the risk of obesity and central adiposity.34 People sleeping 7-8 hours/night night have been shown to accumulate less visceral fat mass than those sleeping for ≤6 hours/night.35 Sleep debt leads to changes in leptin and other hormones related to satiety, greater feelings of hunger, dietary indiscretion and poor food choices, as well as reduced physical activity and insulin resistance.34 In other words, getting that solid sleep needs to be a priority. As well as sleep quantity, sleep quality has to be considered, as poorer sleep quality is associated with higher visceral fat mass.36 Subjective poor sleep quality is linked with altered cortisol response37 and insulin resistance in postmenopausal women.38

by Sara Gottfried, MD and Annalouise O’Connor, PhD

Shared by Dr. Phil McAllister @ Forward Health Guelph

Citations

  1. Yamatani H et al. Association of estrogen with glucocorticoid levels in visceral fat in postmenopausal women. Menopause. 2013;20(4):437-442.
  2. Shen W et al. Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging study. Nutr Metab (Lond). 2009;6:17.
  3. Lovejoy JC et al. Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes (Lond). 2008;32(6):949-958.
  4. de Heredia FP et al. Obesity, inflammation and the immune system. Proc Nutr Soc. 2012;71(2):332-338.
  5. Prior JC. Progesterone for symptomatic perimenopause treatment – progesterone politics, physiology and potential for perimenopause. Facts Views Vis Obgyn. 2011;3(2):109-120.
  6. Hale GE et al. Hormonal changes and biomarkers in late reproductive age, menopausal transition and menopause. Best Pract Res Clin Obstet Gynaecol. 2009;23(1):7-23.
  7. Hale GE et al. Endocrine features of menstrual cycles in middle and late reproductive age and the menopausal transition classified according to the Staging of Reproductive Aging Workshop (STRAW) staging system. J Clin Endocrinol Metab. 2007;92(8):3060-3067.
  8. McTernan PG et al. Glucocorticoid regulation of p450 aromatase acitivty in human adipose tissue: gender and site differences. J Clin Endocrinol Metab. 2002;87(3):1327-1336.
  9. Paredes S et al. Cortisol: the villain in metabolic syndrome? Rev Assoc Med Bras (1992). 2014;60(1):84-92.
  10. Incollingo Rodriguez AC et al. Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: a systematic review. Psychoneuroendocrinology. 2015;62:301-318.
  11. Li S et al. Effects of menopause on hepatic 11β-hydroxysteroid dehydrogenase type 1 actvity and adrenal sensitivity to adrenocorticotropin in healthy non-obese women. Gynecol Endocrinol. 2011;27(10):794-799.
  12. Andersson T et al. Tissue-specific increases in 11β-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women. PLoS One. 2009;4(12):e8475.
  13. Andersson T et al. Estrogen reduces 11β-hydroxysteroid dehydrogenase type 1 in liver and visceral, but not subcutaneous, adipose tissue in rats. Obesity (Silver Spring). 2010;18(3):470-475.
  14. McTernan PG et al. Gender differences in the regulation of P450 aromatase expression and activity in human adipose tissue. Int J Obes Relat Metab Disord. 2000;24(7):875-881.
  15. Castro AV et al. Obesity, insulin resistance and comorbidities? Mechanisms of association. Arq Bras Endocrinol Metabol. 2014;58(6):600-609.
  16. Plymate SR et al. Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J Clin Endocrinol Metab. 1988;67(3):460-464.
  17. Loukovaara M et al. Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cultures by hormones and growth factors. J Clin Endocrinol Metab. 1995;80(1):160-164.
  18. Davis SR et al. The contribution of SHBG to the variation in HOMA-IR is not dependent on endogenous oestrogen or androgen levels in postmenopausal women. Clin Endocrinol (Oxf). 2012;77(4):541-547.
  19. Janssen I et al. Testosterone and visceral fat in midlife women: the Study of Women’s Health Across the Nation (SWAN) fat patterning study. Obesity (Silver Spring). 2010;18(3):604-610.
  20. Klok MD et al. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev. 2007;8(1):21-34.
  21. Engin A. Diet-induced obesity and the mechanism of leptin resistance. Adv Exp Med Biol. 2017;960:381-397.
  22. Harris RBS. Development of leptin resistance in sucrose drinking rats is assocated with consuming carbohydrate-containing solutions and not calorie-free sweet solution. Appetite. 2018;132:114-121.
  23. Diamanti-Kandarakis E et al. Mechanisms in endocrinology: aging and anti-aging: a combo-endocrinology overview Eur J Endocrinol. 2017;176(6):R283-R308.
  24. Levine JA. Sick of sitting. Diabetologia. 2015;58(8):1751-1758.
  25. Boutcher SH. High-intensity intermittent exercise and fat loss. J Obes. 2011;2011:868305.
  26. Maillard F et al. Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis. Sports Med. 2018;48(2):269-288.
  27. Maillard F et al. High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes Metab. 2016;42(6):433-441.
  28. Nunes PRP et al. Effect of high-intensity interval training on body composition and inflammatory markers in obese postmenopausal women: a randomized controlled trial. Menopause. 2018;Oct 1.
  29. Cramer H et al. Yoga for menopausal symptoms-a systematic review and meta-analysis. Maturitas. 2018;109:13-25.
  30. Pascoe MC et al. Yoga, mindfulness-based stress reduction and stress-related physiological measures: a meta-analysis. Psychoneuroendocrinology. 2017;86:152-168.
  31. Caputo T et al. From chronic overnutrition to metainflammation and insulin resistance: adipose tissue and liver contributions. FEBS Lett. 2017;591(19):3061-3088.
  32. Gabel K et al. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: a pilot study. Nutr Healthy Aging. 2018;4(4):345-353.
  33. Sutton EF et al. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab. 2018;27(6):1212-1221.e3.
  34. Koren D et al. Role of sleep quality in the metabolic syndrome. Diabetes Metab Syndr Obes. 2016;9:281-310.
  35. Chaput JP et al. Change in sleep duration and visceral fat accumulation over 6 years in adults. Obesity (Silver Spring). 2014;22(5):E9-12.
  36. Sweatt SK et al. Sleep quality is differentially related to adiposity in adults. Psychoneuroendocrinology. 2018;98:46-51.
  37. Huang T et al. Habitual sleep quality and diurnal rhythms of salivary cortisol and dehydroepiandrosterone in postmenopausal women. Psychoneuroendocrinology. 2017;84:172-180.
  38. Kline CE et al. Poor sleep quality is associated with insulin resistance in postmenopausal women with and without metabolic syndrome. Metab Syndr Relat Disord. 2018;16(4):183-189.

 

Sara Gottfried, MD

Sara Gottfried, MD is a board-certified gynecologist and physician scientist. She graduated from Harvard Medical School and the Massachusetts Institute of Technology and completed residency at the University of California at San Francisco. Over the past two decades, Dr. Gottfried has seen more than 25,000 patients and specializes in identifying the underlying cause of her patients’ conditions to achieve true and lasting health transformations, not just symptom management.

Dr. Gottfried is the President of Metagenics Institute, which is dedicated to transforming healthcare by educating, inspiring, and mobilizing practitioners and patients to learn about and adopt personalized lifestyle medicine. Dr. Gottfried is a global keynote speaker who practices evidence-based integrative, precision, and Functional Medicine. She has written three New York Times bestselling books: The Hormone Cure, The Hormone Reset Diet, and her latest, Younger: A Breakthrough Program to Reset Your Genes, Reverse Aging, and Turn Back the Clock 10 Years.

Annalouise O’Connor, PhD, RD

Dr. Annalouise O’Connor is the R&D Manager for Therapeutic Platforms and Lead for Cardiometabolic and Obesity platforms at Metagenics. Her role involves research coordination, as well as developing formulas for targeted nutrition solutions and programs to assist practitioners in the optimal management of their patients’ health. Annalouise trained as an RD and worked in clinical and public health settings. Dr. O’Connor completed her PhD in the Nutrigenomics Research Group at University College Dublin (Ireland) and postdoctoral work at the UNC Chapel Hill Nutrition Research Institute.

 

Dr. Laura on Mould and Indoor Air Quality

Mould is very important factor in indoor air quality. If you are chronically ill and can’t seem to shake it, test the places you spend time.

Mould Related Health Issues

  • nasal stuffiness
  • throat irritation
  • coughing or wheezing
  • eye irritation
  • skin irritation

The Centre for Disease Control and Prevention  is firm about the removal of any visible mould. Health impacts vary from person to person. Mould, once inhaled, can grow in the lungs and upper respiratory tract. It also has the potential to spread through the rest of the body.

Where is Mould found?

Mould is found where there is moisture, on just about any surface and can be tracked from place to place. Be sure to check basements, bathrooms, laundry room, kitchen, roofs and around leaky pipes. A professional can be hired to investigate anything beyond a visual check. Or if you are up to it, there are some at home kits available. The Amazon DIY Mold kit (Americans spell it without the “u”) or try the Canadian option, which includes air tests at http://www.CanadaMoldTestKits.com‎ (they must sell to Americans!)

What’s the proper indoor humidity?

Too dry and your nasal passages can dry out and make you more susceptible to infection. Too humid and the dampness can be a breeding ground for mould and mildew.

Indoor humidity should be kept around 45-50%.

A humidity reader, also called a hygrometer, is available at any local hardware store. Review and compare some of the best hygrometers evaluated in 2018.

De-humidfiers are helpful in damp spaces. Their filters should be kept clean and collection bins rinsed with white vinegar every couple of weeks. Humidity in Ontario is generally higher spring through fall and drier once the indoor heating starts.

 Health issues persist?

Long term exposure to mould means you need some serious detoxification. If health related mould issues persist, a visit with Dr. Laura may help you clean up the damage and get clear of the problems.

Dr. Laura M. Brown, ND

Dr. Laura on Detoxification

Detoxification is a continual process. This happens at a cellular level throughout the body especially in the liver, kidney, lungs, skin, gastrointestinal tract and emotions.

Cellular toxins

When a cell encounters a toxin, be it too much sugar or alcohol, pesticides, BPA, lead, mercury, cadmium, arsenic, nickel, chemical flame retardants, phthalates, viruses, bacteria, fungi or parasites it mounts a cell danger response (CDR).  This load triggers a series of protective reactions that slows the transport of   goods across the cellular membrane. The membrane walls thicken just like our ancestors ravaged in war, built their walled cities for protection. This response to cellular danger is a fundamental component of innate immunity and can be helpful in times of distress.

Seasonal influence on detoxification

There comes a time when things must come and go from this walled city.  Seasonal influence provide an important basis for organ focus. For example, in the height of summer, the emotions, digestive and energy movement are most active. Autumn is more a time for the lungs and large intestine.  Winter brings the kidney and bladder centre stage. Finally in spring the liver and gallbladder are most ready to clear out the build up from the cold winter months.

Long term effects of toxic exposure

Long term toxic exposure with little support leads to chronic disease. This is when the cells continually want to keep their walls of protection. This is not healthy. Garbage builds up, and the inward flow of nutrients slow down. We also get this feeling after the long, cold winter months as we have hibernated inside, put the heat on and slowed our movement in and out of the house. It is always interesting what tends to happen at human levels of behaviour are also reflected at levels of cellular behaviour.

With this in mind, it might be proactive to think about more outside activities to keep your cells and energy from becoming too stagnant. The kidneys and urinary bladder are likely more open to accept attention in the winter time.  The urinary bladder is pretty straight forward in its function; eliminating water soluble waste that has been prepared by the supporting organs in the body. The kidneys themselves are responsible for blood filtration, mineral and acid base balance. They decide what gets filtered out and what gets recycled back into the body. In Chinese Medicine, the kidneys include the adrenals, our body’s organs that help us adapt to stress.  It is important through the winter months to also ensure the adrenal glands are well supported.

Near the end of one season and the beginning of another, during equinox, the need for the organs shift. So in late winter, early spring, the stage prepares for the kidneys, adrenals and bladder to fade and the liver and gallbladder begin to take centre stage. If the flow of energy through these organs is not smooth, it generally results in a lack of creativity and feelings of irritability and nagging frustration.

Organ System Screening

Electro dermal screening (EDS) can provide insight into the health of your detoxification organs. Much like an EKG on the heart or EEG on the brain, nervous system conductance related to each organ may be captured at peripheral points of the nervous system on the hands and feet. The onsite EDS equipment at Forward Health is German engineered, precise and needle free. 

Detoxification Plan

Together with sensitive body biofeedback from the EDS equipment and understanding what’s bothering you, Dr. Laura M. Brown, ND can create a clear detoxification plan to help you relax those walls you and your cells have built, and get the river of life flowing smoothly once again.

Resources:
Teeguarden, Ron. 1984. Chinese Tonic Herbs. Japan Publications New York.
Naviaux, Robert. 2013. Metabolic Features of the Cell Danger Response. Mitochondrion Volume 16, May 2014, Pages 7-17 https://doi.org/10.1016/j.mito.2013.08.006.

 

Dr. Laura: Why Estrogen Makes You Stressed

How estrogen impacts stress

High levels of estrogen might increase your levels of stress. It clogs up the detoxification pathways and leaves neurochemicals in the body for too long. A build up of neurochemicals can make a person angry, irritable, anxious or exhibit compulsive symptoms.

The detoxification processes affected by high levels of estrogen:

  1. Methylation
  2. Breakdown

Methylation

Methylation keeps cells from oxidizing, aging, or simply “going bad”. Too much or too little methylation is linked to multiple diseases and cancer. Methylation aids in DNA and RNA synthesis, cell differentiation, neurotransmitter synthesis and metabolism, detoxification, hormone clearance, energy production, nerve conduction and histamine clearance.

Methylation is provided by foods that offer sources of B6,B12, zinc and folate (lots of vegetables, fruits, seafood, red meat, nuts & seeds). The MTHFR (methyl folate reduction) gene’s activity is observed through genetic and organic acid tests. Homocysteine can also be a blood biomarker for how well the methylation cycle works.

Breakdown of neurotransmitters

COMT Catechol-O-Methyltransferase (COMT) is one of several enzymes that degrade the neurotransmitters dopamine, epinephrine, and norepinephrine. COMT is heavily influenced by levels of estrogen. When the estrogen is high, the COMT is slowed down.

MAO, or monoamine oxidase, is an enzyme that affects the neurotransmitters dopamine, norepinephrine, and serotonin.

When we think of estrogen, we often think of females with Premenstrual Syndrome (PMS) and peri-menopausal women. These are times when the estrogen surges and drops, inflicting mild to severe mood swings.

Estrogens are not only a female concern. There are increased levels of estrogens in males and females due to environmental factors.

Xenoestrogens are not natural forms of estrogen and the body has difficulty eliminating them. Xenoestrogens come in the form of birth control pills, flame retardants, BPA, pesticides, heavy metals, aluminum, lead, mercury, arsenic and cadmium.

Increased xenoestrogens puts an increased toll on our COMT and MAO. When the COMT and MAO are busy with excess estrogen and  xenoestrogens it makes it more difficult for them to do their everyday job of clearing catecholamines, or brain chemicals like dopamine and adrenaline. When dopamine and adrenaline hang out for too long, the body endures long standing experiences of stress. This is why estrogen detoxification and support of methylation, COMT and MAO activity in general can lead to less anxiety and aggravation.

How well does your methylation, COMT and MAO work?

Find out how your hormones influence your levels of stress through blood,  dried urine, and salivary tests available with Dr. Laura:

Dr. Laura M. Brown, ND works with her patients to help them understand their genetic tendencies and educates on how to prevent disease, reduce experiences of stress and live with energy.

Dr. Laura: Epstein Barr Virus Linked to Several AutoImmune Diseases

The Epstein Barr Virus (EBV) we know mostly as “mono” yields connections to several autoimmune diseases.

Who Gets EBV?

More than 90% of the world’s population is infected with EBV. The age of contraction varies and for many it lays dormant for years. Like other human herpes forms of virus (EBV is HHV4), it reactivates in times of stress or trauma. Typical symptoms are what you hear from the college student and their “kissing disease” – tired, sleep a lot, muscle aches and pains, swollen glands/lymph nodes, altered sense of taste and the list goes on.

It seems that if such a large percentage of the population has EBV, it’s easy to pin it to any disease. Recent research at the Cincinnati Children’s Hospital sheds some light on how EBV affects our genome.

What Diseases Link to EBV?

  • Systemic Lupus Erythematosus (SLE)
  • Multiple Sclerosis (MS)
  • Rheumatoid Arthritis (RA)
  • Juvenile Idiopathic Arthritis (JIA)
  • Inflammatory Bowel Disease (IBD)
  • Celiac Disease
  • Type 1 Diabetes
  • Graves and Hashimotos thyroiditis

“This discovery is probably fundamental enough that it will spur many scientists around the world to reconsider the role of this virus in these disorders,” said John Harley, MD, PhD, director of the Center for Autoimmune Genomics and Etiology (CAGE) at Cincinnati Children’s.

How does EBV Increase Risk for Autoimmunity?

EBV alters the human DNA in ways that weaken the immune system’s ability to combat certain diseases. We all have imperfect genes with variances called SNP’s (pronounced “snips”) that may give us advantage or risk over others in certain situations. EBV tends to change the genetic transcription of DNA to suit its own vitality and puts us more at risk for certain diseases.

What Can Increase the Risk of EBV Sickness?

  • Stress
  • Trauma
  • Poor nutrition
  • Eating the wrong foods
  • Lack of exercise
  • Poor  sleep
  • Lack of spiritual connection

More research is required in this area of science for our full understanding of how to combat this detrimental virus. A Naturopathic Doctor like Dr. Laura M. Brown, ND can help balance lifestyle, diet, nutrition and immune boosting profile to keep the Epstein Barr and other forms of Human Herpes Virus (warts, shingles, cold sores) dormant in your system. Dr. Laura M. Brown, ND can also order and inert genetic tests to help you evaluate your risk for certain autoimmune diseases. Knowing your risk factors can contribute to proactive wellness plan that is tailored specifically to you.